Fred Sack

Faculty Profile

Faculty Profile

Photo by: Elaine Simons Lane
Professor Emeritus

B.A. Sociology (1969) Antioch University; 
Ph.D. Plant Biology (1982) Cornell University; 
Postdoctoral Researcher Boyce Thomson Institute; 
Assistant Professor Ohio State University (1984); 
Associate Professor (1990); 
Professor, 1997-2006; 
Chair Dept. Plant Cell & Molec. Biology, Ohio State Univ. (2004-2006);
Professor UBC Botany, 2006-2014; Head of Botany, 2006-2011

Research Interests

The Sack lab studied the cellular and molecular biology of how stomata develop. Stomata are highly specialized structures made up of two guard cells surrounding a pore. The gating of this aperture in the leaf epidermis regulates the entry of carbon dioxide used in photosynthesis. Using a targeted genetic screen we identified genes critical for stomatal formation. TOO MANY MOUTHS encodes a receptor-like protein whose expression marks a stem cell compartment in the developing shoot epidermis. TMM regulates both the number and orientation of asymmetric divisions that produce stomata. FOUR LIPS encodes a MYB transcription factor that limits symmetric divisions later in the stomatal cell lineage.

Selected Publications

Keerthisinghe, S,   Nadeau, JA, Lucas, JR, Nakagawa, T,  and Fred D. Sack (2015) The Arabidopsis leucine-rich repeat receptor-like kinase MUSTACHES enforces stomatal bilateral symmetry in Arabidopsis. The Plant Journal DOI: 10.1111/tpj.12757

Li, Meng and Fred D. Sack (2014) Myrosin Idioblast Cell Fate and Development Are Regulated by the Arabidopsis Transcription Factor FAMA, the Auxin Pathway, and Vesicular Trafficking. The Plant Cell DOI: http:/ / dx. doi. org/ 10. 1105/ tpc. 114. 129726

EK Lee, JR Lucas, FD Sack (2014)  Deep functional redundancy between FAMA and FOUR LIPS in stomatal development. The Plant Journal DOI: 10.1111/tpj.12489

EK Lee, JR Lucas, J Goodrich, FD Sack (2014) Arabidopsis guard cell integrity involves the epigenetic stabilization of the FLP and FAMA transcription factor genes. The Plant Journal DOI: 10.1111/tpj.12516

Jie Le, Fred Sack, et al. (2014) Auxin transport and activity regulate stomatal patterning and developmen. Nature Communications DOI:10.1038/ncomms4090

Sack FD, Chen JC 2009 Pores in place. Science 323:592-593, Invited Perspective

Bergmann D C, Sack FD 2007 Stomatal development. Annual Review Plant Biology
58: 163-181

Lucas JR, Nadeau JA, Sack FD 2006 Microtubule arrays and Arabidopsis stomatal development. J Experimental Botany 57: 71-79. (pdf)

Lien B. Lai, Jeanette A. Nadeau, Jessica Lucas, Eun-Kyoung Lee, Tsuyoshi Nakagawa, Liming Zhao, Matt Geisler, and Fred D. Sack (2005). The Arabidopsis R2R3 MYB Proteins FOUR LIPS and MYB88 Restrict Divisions Late in the Stomatal Cell Lineage. PLANT CELL 2005 17: 2754-2767. (pdf)

Falbel TG, Koch LM, Nadeau JA, Segui-Simarro, JM, Sack FD, Bednarek SY 2003 SCD1 is required for cytokinesis and polarized cell expansion in Arabidopsis. Development 130: 4011-24 (pdf)

Nadeau J,A and FD Sack 2003 Stomatal development: Cross talk puts mouths in place. Trends in Plant Science 8: 294-299 (pdf)

Geisler M, DO Deppong, JA Nadeau, FD Sack. 2003 Stomatal neighbor cell polarity and division in Arabidopsis. Planta 216: 571-579. (pdf)

Nadeau JA, Sack FD 2002a Stomatal development in Arabidopsis. In: Somerville CR, Meyerowitz EM (eds) The Arabidopsis book. Amer Soc Plant Biol, Maryland, doi/10.1199/tab.0066 (pdf - note 3MB)

Nadeau JA, FD Sack 2002 Control of stomatal distribution on the Arabidopsis leaf surface. Science 296: 1697-1700. (pdf)

Geisler M and Sack F 2002 Variable timing of developmental progression in the stomatal pathway in Arabidopsis cotyledons. New Phytologist 153:469-476. (pdf)

Geisler M, JA Nadeau, FD Sack. 2000 Oriented asymmetric divisions that generate the stomatal spacing pattern in Arabidopsis are disrupted by the too many mouths mutation. Plant Cell 12: 2075-86. (pdf)

Yang M, JA Nadeau, L Zhao, FD Sack 1999 Characterization of a cytokinesis defective mutant (cyd1) of Arabidopsis. J Experimental Botany 50: 1437-1446. (pdf)

Zhao L, FD Sack 1999 Ultrastructure of stomatal development in Arabidopsis (Brassicaceae) leaves. Amer J Botany 86: 929-39. (pdf)

Geisler M, M Yang, FD Sack 1998 Divergent regulation of stomatal initiation and patterning in organ and suborgan regions of the Arabidopsis mutants too many mouths and four lips. Planta 205: 522-530. (pdf)

Larkin J, MD Marks, J Nadeau, FD Sack 1997 Epidermal cell fate and patterning in leaves. Plant Cell 9: 1109-1120. (pdf)

Yang M, FD Sack 1995 The too many mouths and four lips mutations affect stomatal production in Arabidopsis. Plant Cell 7: 2227-39. (pdf)